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Abstract
The review article summarizes the main results of half a century of experimental research of the Department of Endocrinology of Reproduction and Adaptation in the field of congenital defects of the neuroendocrine system caused by pathogenic influences on the mother’s body during critical periods of individual development. A neurochemical concept of androgen-dependent disorders of sexual differentiation of the brain is proposed, which relate to the regulation of ovarian cycles, sexual behavior, the function of the hypothalamic-pituitary-adrenal axis and its response to stress. The role of corticosteroids in the early programming of the hypothalamic-pituitary-adrenal axis of intrauterine fetus is shown. The neurohormonal mechanisms of the pathogenesis of prenatal stress syndrome are revealed and the ways of pharmacological prevention of its negative long-term consequences are outlined. Longterm effects of prenatal exposure to dibutyl phthalate, bisphenol A and ibuprofen as endocrine disruptors were studied. A new syndrome of hypersexuality and hyperandrogenism is described in male rats after maternal exposure to low doses of dibutyl phthalate during the critical period of sexual differentiation of the fetal brain. Conclusions. The research findings indicate the importance of further research in the field of so-called functional teratology. They are the pathogenetic basis for the prevention of a number of neuroendocrine and behavioral disorders.
References
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