Informative properties of repolarization phase indicators on a single-channel electrocardiogram in children with diabetic cardiomyopathy

Abstract

The aim was to study new early markers of diabetic cardiomyopathy (DCM) in children with type 1 diabetes mellitus (DM 1) by analyzing of repolarization phase on a single-channel electrocardiogram (ECG) in phase space under stress testing. Material and methods. 23 children aged 7-16 years with DM 1 were examined. The control group consisted of 22 practically healthy schoolchildren aged 7-15 years. With the help of the FAZAGRAF® complex, traditional and original parameters of repolarization phase of ECG first standard lead in a state of relative rest, immediately after the load (20 squats in 30 sec) and in the third minute of the restitution period were examined and automatically calculated. Results and discussion. In the state of rest in children with DM 1, a flattened and narrow T-wave is seen, and the value of the T-wave symmetry parameter SD βТ is significantly higher. At the peak of the load in children with DM 1 depression of the ST segment was more common, and the T-wave symmetry parameters βТ and SD βТ had more pronounced upward trend. After 3 minutes of rest, in children with DM 1 a persistence of ST-segment depression and significantly higher βТ and SD βТ parameters were identified. The obtained results indicate the development of DCM in children with DM 1 and high risk of cardiovascular morbidity and mortality in adulthood. Conclusions. Examination of children with DM 1 using the portable complex FAZAGRAF®, especially with stress tests, significantly improves the accuracy and informative value of the ECG by analyzing the original myocardial repolarization parameters βТ and SD βТ. Identification of the above changes provides the reason for further in-depth examination of children with DM 1 for the timely detection and subsequent early prevention of diabetic cardiomyopathy.