Relationship between cerebral perfusion and cognitive impairments in patients with type 2 diabetes mellitus according to neuropsychological tests

Abstract

Most studies indicate a deterioration in cerebral perfusion in patients with type 2 diabetes. But studies evaluating cerebral blood flow in patients with diabetes using Single Photon Emission Computed Tomography (SPECT) were single. Therefore, the purpose of our study was to study the relationship between the state of cerebral perfusion and cognitive dysfunction according to neuropsychological tests in patients with type 2 diabetes. Materials and methods. There were 94 patients with type 2 diabetes (62 women and 32 men) included in this study. The mean age is 62.12Ѓ}0.57 year, the average duration of disease is 9.7Ѓ}0.69 year, a level of glycosylated hemoglobin is 8.14Ѓ}0.13%. Evaluation of the disorders in cognitive manifestations was carried out with the help of neuropsychological tests consisting of: 5 words test, MMSE, BPD, RAWLT test, Brixton test, TMT, DSFB, Verbal fluency test, Test symbol, Stroop color test. Cerebral blood flow was assessed using SPECT. Quantitative measurement of cognitive manifestations was carried out for the entire brain, and for certain parts of both hemispheres, namely: frontal, occipital, parietal and temporal, also cerebellum, caudate nucleus, putamen and thalamus. Statistical processing of the results was carried out using the SPSS version 23 for Windows. Results. A negative relationship between cerebral perfusion in the frontal region, the caudate nucleus, the thalamus, the temporal region and the impairment memory function was found. The presence of a negative relationship between the state of the executive function and perfusion characteristics in the frontal lobe, the cerebral cortex on both sides, the left parietal, occipital, temporal areas of the brain on both sides and the left side of the putamen was established. Conclusions. This study showed that disorders of cognitive functions are associated with a decreased cerebral blood flow in patients with type 2 diabetes.