Comparative analysis of ci tological characteristics of beni gn and malignant thyroid tumors in intraoperative cytological examinations

Abstract

Using the intraoperative cytologic examinations (ICE) increases the effectiveness of the detection of papillary thyroid carcinoma (PTC). For analyzing the cytological preparations during ICE, the same criteria as during the evaluation of the smears, obtained during fine needle aspiration biopsy (FNA), are used. However, both, the way of taking the material and the technique of staining are different, also the time for analyses is very limited. Aim was to analyze the frequency of  cytological sings, specific for PTC, in different thyroid tumors. Material and methods. There were analyzed 879 thyroid tumors, in which ICE were carried out. In accordance with the final histological diagnosis, the distribution of studied tumors was as follows: 501 — PTC, 59 — follicular thyroid carcinoma, 209 — follicular thyroid adenoma, and 110 — nodular goiter. Results. Based on the results of the analysis, the accuracy, specificity and sensitivity of such cytological signs of PCH in assessing the results of IRC, such as the presence of papillary structures, the absence of a colloid, the degree of preservation of tumor cells with enlarged, light nuclei and abundant, vacuolated cytoplasm, the presence of true intranuclear inclusions, pseudo-grooves and psamomma bodies and others were established. Conclusion. The carried out analysis found that as important cytological sings of PTC should be allocated the following: the presence of papillary structure, absent of colloid, multycellularity with a compulsory high degree of preservation of tumor’s cells with enlarged, light nuclei and abundant, vacuolated cytoplasm, as well as the presence of intranuclear inclusions (even 1-2) and pseudo inclusions, grooves and psamomma bodies.