The involvement of transcriptional factor AP-1 of the N-acylethanolamines signal transduction in the human adrenocorticocytes
Vol. 20 No. 1 (2015), ORIGINAL PAPERS
Vol. 20 No. 1 (2015)

The involvement of transcriptional factor AP-1 of the N-acylethanolamines signal transduction in the human adrenocorticocytes

ORIGINAL PAPERS
Published March 15, 2015
O.I. Kovzun
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine»
О.S. Lukashenia
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine»
O.A. Gornostal
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine»
A.S. Mikosha
State Institution «V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine»
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Keywords

transcription factors
signal transduction
adrenal cortex
N-acylethanolamines

How to Cite

Kovzun, O., LukasheniaО., Gornostal, O., & Mikosha, A. (2015). The involvement of transcriptional factor AP-1 of the N-acylethanolamines signal transduction in the human adrenocorticocytes. Endokrynologia, 20(1), 396-400. Retrieved from https://endokrynologia.com.ua/index.php/journal/article/view/201
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Abstract

The messenger mechanisms mediating cannabinoids regulatory signals in the adrenal cortex were studied. The aim of the work was to measure levels of transcription  factors с-jun and с-fos in human adrenal cortex after N-acylethanolamines (NAE) treatment. The role of transcription factors c-fos and c-jun, which are included in AP-1  factor, attracts attention in realization of NAE signal transduction. Level expression of c-jun increased 50% after 10 μM NAE treatment, c-fos increased 3-fold after NAE  treatment. Together these finding suggest that transcriptional factors с-jun  and c-fos mediate NAE signal transduction in human adrenocorticocytes.

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Copyright (c) 2015 SI ≪V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine≫

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