Abstract
The lecture is devoted to questions of osteoartropathy in diabetes mellitus. The authors discuss the current definitions of osteoartroartropaties, their prevalence, clinical manifestations and peculiarities of diabetes mellitus and metabolic syndrome. The degradation of articular cartilage, subchondral bone restructuring and inflammation are considered the key mechanisms in the etiology of osteoarthritis. Metabolic disorders associated with the factors of the metabolic syndrome and diabetes mellitus: total and abdominal obesity, insulin resistance, glucose toxicity, oxidative stress, dismetabolism of lipids and purines attributed to the pathogenetic mechanisms of the development of degenerative dystrophic changes in the joints. For diabetes mellitus is typical imbalance of proinflammatory and anti-inflammatory cytokines, prostaglandins, growth factors that induces the processes of inflammation and degradation of articular cartilage, creating the basis for clinical manifestations of osteoarthritis signs.