Description of the reproductive organs of male rats after application of a monodispersed solution of gold nanoparticles

Abstract

Object. To study the effect of monodispersed colloidal solution of 20 nm gold nanoparticles on reproductive organs of mature and stimulated by testosterone  propionate immature castrated male rats. Materials and methods. The solution of gold nanoparticles had been administered intraperitoneally or subcutaneously at a  dose of 0.3 mg/kg or 10 mg/kg body weight (for the metal content) during 6 or 14 days. There were determined the mass of organs, their morphology structure and  contents of nucleinic acids. Results. The gold nanoparticles preparation did not affect the mass and histology structure of the testicles, mass of the epididimises,  coagulating the glands and the seminal vesicles. An inflammatory process had been observed in the ventral prostate of mature animals. The mass of the ventral  prostate, coagulating the glands and the seminal vesicles, as well the content of nucleinic acids in the ventral prostate of immature castrated rats against a  ackground  of hormone replacement therapy did were not changed after the gold nanoparticles administration. There were revealed enhanced blood supply and moderate  leukocyte infiltration in ventral lobe of the prostate. Conclusion. Colloidal solution of 20 nm gold nanoparticles caused the inflammatory response in the rat ventral  prostate while there were no changes in accessory sexual glands and gonads.