The efficacy of using the complex of alpha-lipoic acid and zinc sulfate in the correction of dyslipoproteinemia in postinfarction patients with type 2 diabetes mellitus

Abstract

Aim of the work is to study the dynamics of the lipid metabolism indices in patients with type 2 diabetes mellitus who had non Q myocardial infarction against a  background of using the drugs of alpha-lipoic acid and zinc sulfate. Materials and methods. The indices of lipid metabolism and their dynamics of 49 postinfarction  patients with type 2 diabetes mellitus under the effect of 4-month combined treatment with alfa-lipoic acid and zinc sulfate were studied. Results. A decreased levels of  T-Chol (p<0.01), LDL-Chol (p<0.05), TG (p<0.05), VLDL-Chol (p<0.05) and Apo B (p<0.05), which caused a decrease in CA (p<0.05) and the ratio of Apo B / Apo A-1  (p<0.01) were revealed against a background of the treatment. A positive tendencies to decrease in the LP (a) level — p<0.2 and to increased Apo A-1 concentration  (p<0.2) were fixed. Conclusion. The 4-month use of alpha-lipoic acid and zinc sulfate in the complex treatment of patients with type 2 diabetes mellitus, who had non Q  yocardial infarction, causes a decrease in the levels of atherogenic LDL-Chol, TG, VLDL-Chol and Apo B protein, contributing to the reduction of T-Chol and CA, and  positively influencing on the prognostic significant ratio of Apo B / Apo A-1.