Effect of hypoglycemic therapy on cognitive function in elderly patients with type 2 diabetes mellitus

Abstract

Aim of study is to determine the effect of different type of hypoglycemic therapy on cognitive status in elderly patients with type 2 diabetes mellitus. Material and methods. 115 patients aged 65-81 years were examined. They were divided into groups depending on the type of hypoglycemic therapy. The first group included patients treated with diet therapy; the second — metformin; the third — sulfonylurea; the fourth — metformin + sulfonylurea; fifth — sulfonylurea + metformin DPP‑4, GLP‑1, inhibitors of sodiumglucose cotransporter type 2; the sixth — those who took insulin; the seventh — insulin + metformin + sulfonylurea / insulin + metformin. For the assessment of cognitive function were used the following
methods: test «5 words», Schulte test, MMSE, BLD, clock drawing test. Results. In the overall assessment of cognitive functions with MMSE scale significant no difference were revealed between groups but the worsening of this indicator in all groups of patients and was in accordance with predement cognitive impairment. There was no significant difference in the evaluation test «5 words», and Schulte table between groups. Under studying BPD the worst index was in the group of diet and in sulfonylurea group, while the best index was in the group treated with clean metformin and metformin + sulfonylurea group + DPP‑4/GLP‑1/ inhibitors of sodium-glucose cotransporter type 2.